Naturwissenschaftlicher Doktorand

Universitätsklinikum Erlangen
Molekulare Neurologie
PD Dr. med. Martin Regensburger
Schwabachanlage 6
91054 Erlangen

Ihre Ansprechperson bei Fragen

PD Dr. med. Martin Regensburger

09131/ 85-39324

Naturwissenschaftlicher Doktorand / PhD student position (M/F/d): Inflammation in Motor Neuron Diseases

**Veröffentlicht seit**: 24.04.2023

**Job-Nr.**: 5788

Ihre Ansprechperson bei Fragen

PD Dr. med. Martin Regensburger

09131/ 85-39324

Anschrift

Universitätsklinikum Erlangen
Molekulare Neurologie
PD Dr. med. Martin Regensburger
Schwabachanlage 6
91054 Erlangen

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Naturwissenschaftlicher Doktorand / PhD student position (M/F/d): Inflammation in Motor Neuron Diseases

**Veröffentlicht seit**: 24.04.2023

**Job-Nr.**: 5788
Universitätsklinikum Erlangen
Molekulare Neurologie
PD Dr. med. Martin Regensburger
Schwabachanlage 6
91054 Erlangen
Ihre Ansprechperson bei Fragen

PD Dr. med. Martin Regensburger

09131/ 85-39324

Klingt spannend?

**Das sind wir**:
State-of-the-art medicine and nursing care you can rely on - Since being founded in 1815, Universitätsklinikum Erlangen has offered medicine of the highest standard and incorporated the latest insights from medical research and state-of-the-art equipment into diagnosis and therapy. More than 9.500 employees from approximately 50 different occupations are needed to provide the wide range of services offered by Universitätsklinikum Erlangen, ensuring our patients receive the very best care around the clock.

At the crossroads of neurodegenerative diseases and neuroinflammation, we are offering a PhD position on an innovative approach to combine clinical and preclinical data. Altered peripheral and central nervous system immune mechanisms are an emerging factor influencing disease onset and course of motor neuron diseases. The present project aims to comprehensively integrate multimodal data derived from in vivo and in vitro studies in a translational way, in order to develop new diagnostic and therapeutic approaches. To this end, the PhD project will have a focus on in vitro analysis of motor neurons, microglia, peripheral immune cells, complemented by clinical data.
We offer the opportunity to work both with clinical data and in vitro models, in the framework of a structured educational PhD program, qualifying for a future scientific career as medical scientists at the interface between clinical and biological research

Die Aufgaben

Working with preclinical in vitro models (2D human stem cell based models including iPSC derived microglia and motor neurons; primary patient derived cells including peripheral blood derived mononuclear cell phenotyping and stimulation and primary fibroblasts)
Application of an array of routine molecular biology analysis techniques, as well as novel state-of-the-art approaches for handling RNA
Preparation, execution and evaluation of Multi-OMIC data (Transcriptomics, Metabolomics, Imaging)
Application of machine learning-based analysis

Das Know-how dafür

Master’s Degree (or equivalent) in Life Science and excellent academic performance
Practical and theoretical experience in the field of molecular biology, immunology or cell biology
Very good knowledge of English
High level of motivation, ambition and scientific interest

Zusätzlich von Vorteil

Experience with experimental work in the lab
Experience with bioinformatic data analysis

Das bieten wir

A crisis-proof job with all the comforts of a collective agreement, including additional pensions from the federal and state pension scheme (VBL), with us as a systemically important employer in the public sector
An interesting job in a motivated, open-minded team
Careful and qualified training
A comprehensive offer for health promotion
Intended classification, depending on qualifications and personal requirements, according to TV-L

Arbeiten am UKER
Wir zählen zu den besten Krankenhäusern Deutschlands und sind einer der größten Arbeitgeber in Mittelfranken. Diesen Erfolg erarbeiten tagtäglich unsere über 9.500 hoch qualifizierten Beschäftigten in unterschiedlichsten Berufen. Wir als Uniklinikum Erlangen wissen, dass alle unsere Beschäftigten wichtig sind, damit auch in Zukunft modernste Medizin, ausgezeichnete Forschung und Patientenversorgung auf höchstem Niveau gelingen.
Wenn Sie sich eine Tätigkeit mit einem hohen sozialen Wert wünschen und die Welt der Spitzenmedizin mit uns gemeinsam gestalten und ermöglichen möchten, dann sind Sie bei uns richtig