Computational Biologist as Postdoc

vor 4 Wochen

Heidelberg, Baden-Württemberg, Deutschland Universitätsklinikum Heidelberg Vollzeit

The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 14,000 employees in more than 50 specialized clinical departments with almost 2,500 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.

Postdoctoral Position in Computational Neuropathology: Multi-Omics Data Integration (m/f/d)

wanted for the next possible date at the Neuropathology Department at Heidelberg University Hospital

  • Job-ID: V000013827
  • Field of application: Neuropathologie
  • Location: Heidelberg
  • Job Category: Science and teaching
  • Working hours: full-time (100 %)
  • Limitation: Temporary (24 Month, Permanent employment/continued employment is being sought)
  • Contract: TV-L

Are you interested in advancing research at the intersection of bioinformatics, computational neuropathology, and multi-omics integration? Join the team at Heidelberg University Hospital, renowned for its pioneering work in molecular diagnostics and home to one of the largest and most comprehensive databases of molecular, histopathological and clinical data in the world.

We are seeking a highly motivated Postdoctoral Researcher with expertise in large-scale omics data analysis to establish an innovative multi-omics data integration workflow. This unique position offers the opportunity to work at the forefront of molecular neuropathology and make a significant impact on the future of precision diagnostics and research in brain cancer and beyond.

Your tasks

As a key member of our interdisciplinary team, you will:

  • Harness a comprehensive dataset spanning digital pathology images, methylation profiles, DNA and RNA sequencing, proteomics, single-cell, and spatial transcriptomics data.
  • Develop and implement a scalable multi-omics analysis blueprint, combining existing tools with the development of innovative approaches (including state of the art deep learning applications) for efficient data integration.
  • Generate actionable insights to advance both diagnostic applications and fundamental research in neuropathology.
  • Establish a generalizable workflow for multi-omics data integration and interpretation that can easily be adapted for different tumor entities and applications.
Your Profile
  • A PhD in Bioinformatics, Computational Biology, or a related field
  • Proven experience in large-scale omics data analysis, preferably spanning multiple omics domains (e. g. methylation profiling, DNA / RNA sequencing, proteomics, single-cell or spatial transcriptomics, or digital pathology)
  • Strong programming (Python / R) and analytical skills, with proficiency in bioinformatics tools, statistics and machine learning. Experience with SQL databases is preferred
  • A creative and problem-solving mindset, capable of translating complex datasets into actionable workflows and meaningful biological insights
  • Excellent written and verbal communication with a proven ability to collaborate effectively in a multidisciplinary environment
What we offer
  • Goal-oriented, individual training and development opportunities (e. g. multi-omics integration, computational proteomics, etc.)
  • Working with the latest techniques / technical equipment for molecular diagnostics and computational neuropathology, including bulk, single-cell and spatial sequencing, mass spectrometry based proteomics and digital pathology images
  • Flexible working hours within the framework of flexitime
  • Possibility of habilitation
  • Possibility to publish scientifically is offered and supported
  • Regular team meetings
  • Interdisciplinary cooperation with leading experts in the fields of neuropathology, molecular biology and computer science
  • Access to one of the most comprehensive molecular datasets available, integrating cutting-edge technologies
  • A vibrant academic setting in Heidelberg, one of Europe's top research hubs

Note: The UKHD is subject to the provisions of the Infektionsschutzgesetz. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.

The UKHD embraces diversity and values diversity.

Regardless of age, gender, personal identity, disability, origin or religion, we offer everyone the same opportunities. If one gender is underrepresented in a particular area, we place particular emphasis on counteracting this imbalance. If they have the same aptitude, qualifications and professional performance, we give priority to people with severe disabilities when considering them for vacancies.

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