IMT 01-2024 Bachelor-

Vor 3 Tagen


Karlsruhe, Deutschland karlsruher institut für technologie Vollzeit

Job descriptionTools for bioanalytical applications include enzyme-linked immunosorbent assays (ELISA) and biosensor measurements. They enable heterogeneous assays for the detection of biomolecules in a wide range of applications, such as the detection of disease markers in blood or contaminants in food or environmental samples. The assays are mostly based on the lock-and-key principle, where one of the binding partners is immobilized on the device surface. Surface functionalization techniques to prepare the devices for the analytical applications must take into account the physical and chemical stability of the materials involved. While ELISAs are usually performed in microplates made of polymers, the materials used in biosensor setups are more diverse; and the use of polymers may be limited to the encapsulation of the actual biosensor unit. The focus of this work is to develop and characterize chemical biofunctionalization methods, that are compatible with typical polymers used in bioanalytical applications.Your tasks include:Selection of polymers for testingStability testing of selected polymers using biofunctionalization chemicals derived from standard protocolsSubstitution of incompatible chemicalsTesting standard and revised protocols in ELISAsTesting standard and revised protocols in biosensor measurements using surface acoustic wave (SAW) resonatorsThe number and depth of the tasks will be adapted to the type and length of the work, i.e., bachelor or master thesis. The thesis can be written in German or English.Starting dateby appointmentPersonal qualificationStudy of a relevant subject, such as chemistry, biochemistry, analytical chemistry, bioanalytics, chemical engineering, bioengineering, biotechnologyKnowledge of chemistry, including chemistry laboratory coursesWillingness to work in a multidisciplinary environment


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    vor 3 Wochen


    Karlsruhe, Deutschland Springer Nature Vollzeit

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    vor 2 Monaten


    Karlsruhe, Deutschland Karlsruher Institut für Technologie Vollzeit

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