Doctoral Researcher

vor 1 Woche

Saarbrücken, Saarland, Deutschland Helmholtz-Zentrum für Infektionsforschung GmbH Vollzeit
**Job advertisement no. 040/2024
The department
MICA - Anti-infectives from Microbiota, led by Prof. Christine Beemelmanns at the
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS) in Saarbrücken, is offering a position as

Doctoral Researcher (f/m/d)

Project title:
Structure Elucidation, Total Synthesis and Chemical Biology of Bioactive

Marine Natural Products
In our ERC-funded research project (Starting Grant MORPHEUS), we study the function and origin of natural

products in the interspecies interaction between marine bacteria and marine eukaryotes. Since natural products

with high bioactivities are often produced only in minute abundancies, we use total synthesis to elucidate the

structure of novel natural compounds, test their biological activity and use derivatives thereof for structure-activity

relationship (SAR) and mode of action (MoA) studies.

In light of our recent studies on a novel microbial natural products of marine origin that exhibits unusual antibiotic

activities, we are looking for a highly motivated organic chemist or chemical biologist to join our lab at the interface

between chemistry and biology. To enable the determination of the absolute structure of this peculiar marine

natural product, we have elaborated on two retrosynthetic approaches to reach the goal of its total synthesis.

optimize synthetic steps and finalize the synthesis of natural product as well as derivatives. The intrinsic

bioactivities of the natural product will allow plethora of bioactivity studies in the final phase of the PhD project

and analytical methods for the in depth study of novel biological active compounds.

The PhD project encompasses several key components and tasks:1.

Total Synthesis of Natural Products:

  • Retrosynthetic analysis of natural products.
  • Optimization of synthetic methodologies for precursor synthesis.
  • Multistep synthesis of natural products and their corresponding derivatives for structure
elucidation purposes and biological testing (SAR-studies).

2.

Design of Chemical Probes derived from Natural Products:

  • Design and synthesis of chemical probes allowing mechanism of action studies using different
click chemistries (e.g. SuFEx, cycloaddition, thiol-ene, etc.).

  • If interested, pulldown or proteomics experiments can be performed together with colleagues
from biology/biochemistry.

3.

Isolation and Structure Elucidation of Natural Products from Marine Origin:

  • Collaborate with colleagues from biology to further purify natural products from microorganisms
using various chromatographic techniques (ion exchange, size exclusion, C18 and high pressure

liquid chromatography).

  • Structure elucidation of related natural products (NMR, MS2, xray, chemical derivatization).
  • Optional: Fermentation of microorganisms and optimization of the process to increase natural
product production.

Qualifications:

Master degree or equivalent in (Bio) Organic Chemistry or Chemical Biology.

Strong hands on experience in multi-step synthesis, purification (HPLC) as well as characterization (NMR,

MS, IR, UV, etc.) of organic compounds.

Good understanding of biochemical methods and the willingness to acquire knowledge regarding chemical

biology and ecology to be able to fully integrate into our interdisciplinary team.

Experience in stereoselective synthesis and the preparation of chemical probes is a plus.

Ability to pay attention to details, pursue research independently and work in a goal-oriented manner.

Willingness to work in a plural, collegial, international (co-workers come from 30+ countries) and

interdisciplinary environment.

Excellent English communication skills (written and spoken); very good skills in scientific writing

Disabled persons are given preference in the case of equal professional qualification. The HIPS aims for a

corporate culture of appreciation and promotion of equal opportunities between women and men. The position is

suitable for part-time work.

We offer:

modern laboratories and state-of-the-art instrumentation

a dynamic and international research environment

extensive further training opportunities and the opportunity to enroll in a structured PhD program

unique network of excellent partners to support your research endeavors

30 days vacation & are considered as completely free days)

an annual additional payment (Weihnachtsgeld) analogue to - 20 TVöD

social security included

flexible working hours

The Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) focusses on identifying and developing
new treatment options for infectious diseases with an emphasis on natural product research. Especially
researchers in the department of _Microbial Natural Products_ are aiming to identify, investigate and optimize novel
microbiology, molecular biology and biochemistry. HIPS was jointly started in August 2009 by the HZI in
Braunschweig and Saarland University on Campus Saa

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