Phd Student

Beschreibung:

» Your tasks:

The Jachimowicz lab "Mechanisms of DNA Repair" investigates how defective DNA repair rewires ageing
- and cancer pathways. A multitude of DNA-repair pathways ensure genomic integrity in a healthy cell. Disbalances or dysfunctionalities in these pathways can lead to genomic instability, which is a central contributor to carcinogenesis and ageing. Our research aims to provide a better understanding of the relationship between genome maintenance, ageing, and cancer, in an interdisciplinary approach. We dissect defects in DNA repair pathways in patients with genome instability syndromes and in patients suffering from mantle cell lymphoma, a mature B-cell lymphoma typically affecting the elderly. For patients suffering from mantle-cell lymphoma, mechanism-based therapies are scarce with poor overall treatment outcome. You will investigate the mechanisms underlying this disease and potential therapeutic approaches with a wide range of tools involving biochemistry, cell biology, and computational biology, and transfer these findings to modern genetically engineered and patient-derived mouse models. Your tasks include, but are not limited to, multimodal phenotyping of novel murine MCL in vivo models (IHC, FACS, NGS techniques), functional validation in MCL in vitro models (cell culture, spheroid culture) and integrative analyses with multi-omic data from large MCL patient cohorts.

We seek a highly motivated and talented scientist to join our enthusiastic and collaborative team in an outstanding scientific environment to take part in our exciting research.

» Your Profile:

Applicants should have a Master's degree and a solid background in molecular biology, cell biology, genetics, biochemistry, or bioinformatics. Experience or willingness to work with mouse models is a plus. The applicant should have a keen interest to investigate the interplay between DNA repair mechanisms and cancer. The working language is English; knowledge of German is not required.

» Our Offer:

Find more information about our research group here:

» Your future with us:

Working at the University Hospital Cologne and the Medical Faculty means helping to shape the future - the future of medicine, of patients and, of course, your own future.

You benefit from 59 clinics and institutes as well as numerous other departments and facilities and more than 10,000 jobs.

The Faculty of Medicine of the University of Cologne and the University Hospital Cologne assume important social tasks in research, teaching and patient care.

A close network with many university and non-university partners guarantees an internationally successful science and the excellent education of our students.

» Your future in detail:

We offer a great work environment, intensive mentoring and several interactions with global leaders.

Our young and dynamic group is located at the Max-Planck Institute for Biology of Ageing (MPI-Age), which is equipped with state-of-the-art technology and excellent core facilities.

Situated on the campus of the University Hospital of Cologne, the institute provides outstanding research opportunities for its scientists and a truly interdisciplinary working environment.

At the moment, we host employees from more than 35 different nations worldwide.

Ansprechpartner/in für Fragen:

Contact:
Dr. Melanie Thelen

Application deadline:

Anschrift für Bewerbungen:

Postal address:
Universitätsklinikum Köln AöR

PA30
Geschäftsbereich Personal
50937 Köln

Informationen zur Stelle:

Veröffentlicht

• Mai 2023

Ort

Köln

Link zur Homepage des Krankenhaus

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