PhD student or Postdoctoral researcher

vor 4 Wochen

Bonn, Deutschland Universitätsklinikum Bonn Vollzeit

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.

The Institute of Biochemistry and Molecular Biology, Medical Faculty of the University of Bonn, Germany is offering a full-time (38.5 h/week) position for a

PhD student or Postdoctoral researcher (m/f/d)

The position starts as soon as possible and is for a period of three years, with the possibility of an extension.

Mitochondria fulfil various essential functions for the survival of eukaryotic cells. Their biogenesis and functions depend on the import of more than 1,000 different proteins that are produced as precursors on cytosolic ribosomes. Mitochondrial protein import is an essential process for cell survival and defects cause severe neurodegenerative diseases and cardiomyopathy. The translocase of the outer mitochondrial membrane (TOM complex) forms the entry gate for precursor proteins, which are subsequently sorted via dedicated protein machineries into the different mitochondrial subcompartments. Our biochemical and proteomic studies identified partner proteins of protein translocases, linking protein import to organelle-contact sites, protein quality control mechanisms and mitochondrial metabolism (Mårtensson et al., 2019 Nature; Ellenrieder et al., 2019 Mol. Cell). In the frame of the DFG-funded priority program SPP2453, we will investigate molecular mechanisms that control protein transport to mitochondria.

We use highly innovative techniques in biochemistry, molecular and cell biology such as protein-protein-interaction studies coupled with proteomics, activity assays, blue native electrophoresis, cell-free protein synthesis and protein stability assays. We offer a well-equipped workspace in an active international team. The University of Bonn provides an excellent scientific research environment.

The ideal candidate will be a highly motivated, team-oriented graduate with a strong interest in protein biochemistry, molecular and cell biology. Experience with biochemical, cell and molecular biology techniques or proteomics is advantageous. Candidates should hold a diploma or a master's degree in Biology, Biochemistry, Molecular Medicine, Chemistry or a related subject.

Responsible and versatile: a job with a lot of creative freedom in a collegial team Secure in the future: fee according to TV-L EG13 Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leave Provision for later: company pension scheme Clever to work: possibility of an interest-free loan to buy an e-bike Tailor-made education: subsidized further education and training Systematic start: structured induction Healthy at work: numerous health promotion offers, free membership in UKBfit Employer benefits: preferential offers for employees (corporate benefits)

The University of Bonn is committed to diversity and equal opportunity. It is certified as a family-friendly university. It aims to increase the proportion of women in areas where women are under-represented and to promote their careers in particular. It therefore urges women with relevant qualifications to apply. Applications will be handled in accordance with the Landesgleichstellungsgesetz (State Equality Act). Applications from suitable individuals with a certified serious disability and those of equal status are particularly welcome.

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