Phd student ‒ cell biology and immunology

vor 1 Monat


Göttingen, Deutschland Fraunhofer-institut Für Translationale Medizin Und Pharmakologie Itmp Vollzeit

The Fraunhofer-Gesellschaft currently operates 76 institutes and research institutions throughout Germany and is the world's leading applied research organization. Around 30 800 employees work with an annual research budget of 3.0 billion euros. The Fraunhofer branch »Translational Neuroinflammation and Automated Microscopy« in Göttingen is part of the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP. Here, we focus on understanding pathological and immunological mechanisms in the development and progression of demyelinating diseases of the central nervous system. Multiple Sclerosis is an inflammatory demyelinating disease of the central nervous system. For relapsing-remitting multiple sclerosis, major advances have been made in the development of various disease-modifying therapies that effectively reduce the number and severity of new relapses as well as MRI activity. During the progressive stages of multiple sclerosis, in which new lesions become less frequent and the progression is characterized by a steady increase in neurological disability, most of the drugs on the market are unable to prevent disease progression. The aim of this study is to test suitable candidates for the treatment of progressive multiple sclerosis via animal models and in vitro analysis. For in vivo experiments, we will utilize the murine multiple sclerosis model for experimental autoimmune encephalomyelitis as well as the cuprizone-induced model of demyelination. For in vitro experiments, primary cell cultures of CNS-resident cells will be used. The main methods of this study will be among others flow cytometry, magnetic-activated cell sorting, ELISA, q PCR and immunohistology. APCT1_DE


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